Salary: strong>15-30K
Experience requirements: strong>Unlimited experience
Educational requirements: PhD or above
Job Description: strong>
1、 Laboratory Introduction
Dr. Wang Jiongqian entered the University of California, Davis in 2014 and obtained a Bachelor of Science degree in Theoretical Physics, Biochemistry, and Molecular Biology in 2017. In 2018, he entered the doctoral program in Biological Physics, Structure and Design at the University of Washington. After graduating with his PhD in 2022, he stayed at the university for postdoctoral research. During this period, his main research achievements were published in journals such as Science, PNAS, NSMB, and Nature. Dr. Wang Jiongqian joined the School of Life Sciences and Emergency Medical Center of Westlake University full-time in January 2024, serving as a researcher and assistant professor
Laboratory direction
In the past decade, we have accumulated a wealth of knowledge about the "first contact" between viruses and hosts, as well as the mechanisms of virus entry and fusion. But little is known about what happens after the virus enters the host cell. Especially regarding the release, assembly, and budding processes of viral genetic material, there is currently no detailed molecular level description available. This situation hinders the development of drugs targeting the virus assembly mechanism and virus budding process
Therefore, the laboratory will use single-molecule cryo electron microscopy, cryo electron tomography imaging, and protein-protein interaction related techniques to perform in situ structural analysis of virus systems and their receptor cells that may become pandemics but have not been fully described. The laboratory will focus on the Langya virus and Alongshan virus as the main research objects, and provide structural descriptions of their entry, replication, release, and infection mechanisms. The results will be combined with immunology and translational medicine laboratories to promote the establishment of a virus prevention "arsenal" to respond to possible virus overflow events. After the experimental strategy and design are mature, in situ structural research can be extended from virology to pan cellular biology. At the same time, the laboratory will also develop an ultra high speed frozen electron tomography sample preparation system, which enables in-situ structures to have "temporality" and the ability to accurately locate the starting point of virus host cell interaction and prepare samples at specific time points, in order to achieve the concept of in-situ structural biology with time resolution
2、 Recruitment positions and conditions
Recruitment position: Postdoctoral (2-3 positions)
Job requirements:
1.?? Ability to independently design experimental procedures based on a given research direction
2.?? Have obtained or about to obtain a doctoral degree; During my doctoral studies or in the past two years, Have published one or more papers as the first author in the following related fields, with priority given to international journals
3.?? Applicants must meet at least one of the following criteria, and those with multiple qualifications will be given priority consideration
(1) (Virus direction) requires a research background in relevant disciplines such as virology, cell biology, immunology, biochemistry, and molecular biology. Solid knowledge of virus and cell biology, as well as sufficient knowledge of immunology, are required. Experience in studying live pathogens is required. Priority will be given to those with P2 or above qualifications
(2) (Structural biology direction) requires a research background in related disciplines such as structural biology and biophysics. Ability to independently analyze given proteins and protein complexes (from recombinant protein plasmid design to data analysis and structural construction) is required. Candidates with cryo electron microscopy background are preferred (crystallographic background is also acceptable), and those who can independently operate electron microscopes (or corresponding instruments) are preferred
(3) (Method development direction) Applicants must have a research background in engineering, applied physics (mechanics or optics related), bioengineering, and other related disciplines. Solid proficiency in using CAD or other related software is required, and experience in industrial grade 3D printing is preferred
4.?? Priority will be given to those with certain programming skills
5.?? Strong writing and communication skills in both Chinese and English, with English as the working language preferred
Please send your CV or resume as an attachment to the following email address:
mailto: rbhr@hrcenter.co.uk
With the subject line formatted as: 'Name + Position + Company Name + Location'.