Salary: strong>30-60K
Experience requirements: Strong>3-5 years
Educational requirements: PhD or above
Job Description: strong>
1. Set up biological assays and complete biological analysis projects.
Establishment of biological analysis methods and completion of various analysis tasks
a) Setup antibody related biological analysis: affinity assay, specificity validation, cellular binding assay, endocytotic assay, antibody humanization, antibody expression, and so on.
Familiar with various biological analysis methods for antibody validation, including affinity, specificity validation, cell line binding detection, endocytosis detection, humanization, antibody expression, etc
b) Setup ADC (including linker and payload) in vitro activity assays and safety evaluation assays, such as building target overexpression cell line, cellular cytotoxicity assay, bystander effect assay, PBMC activity assay, ADCC/ADCP/CDC activity assay, satbility assay.
Establish in vitro cell viability and safety evaluation methods for ADC (including linker and payload), such as target overexpression cell line establishment, cell killing analysis, bystander effects, PBMC activity, ADCC/ADCP/CDC activity, stability evaluation, etc
c) cooperated with outside resource to complete ADC in vivo efficacy and safety evaluation.
Establish or collaborate to complete ADC animal efficacy model analysis and pre toxicity safety assessment
d) manage the team to complete customers' or company R&D analysis projects
Lead the team to complete the corresponding analysis tasks
e) cooperate with CMC and IND teams to solve technical problems, and prepare the materials for IND.
Cooperate with CMC and IND teams to complete necessary technical problem resolution and preparation of application materials
2. Laboratory management Laboratory management
a) Be responsible for the drafting, release, upgrading and other work of SMP/SOP documents.
Responsible for drafting, publishing, and upgrading SMP/SOP documents
b) Ensure the relevant requirements of laboratory 5S management.
Ensure the relevant requirements of laboratory 5S management
3. Team building and management Team building and management work
a) Cooperate with recruitment work and complete team formation.
Cooperate with recruitment work and complete team building
b) Regular team training on their professional skills
Regularly train team members on their professional skills
c) Regular summarization on the progressing in ADC
Regularly track the progress of ADC or pharmaceuticals, conduct comprehensive evaluations and summaries
Qualifications for the position:
1. Ph.D, oncology, cellular biology, immunobiology, biochemistry.
Doctoral degree, majoring in oncology, cell biology, immunology, biochemistry, or related fields
2. More than 3 years of experience in biological analysis for antibody related drugs. Preferably with ADC, linker, and payload experience. Preferably experience on antibody discovery, antibody engineering, bispecific antibody.
More than 3 years of experience in biological analysis of antibody drugs. Having ADC drugs or linkers, experience in payload is preferred. Experience in antibody development, antibody engineering, and bispecific antibodies is preferred
3. Familiar with in vivo and in vitro efficacy and safety evaluation of ADC or other antibody related drugs, such as cellular based cytotoxicity assays, PMBC activity assays, CDX/PDX models, DMPK, NHP toxicology.
Familiar with various in vitro and in vivo efficacy and safety evaluations of ADC or antibody drugs, such as cytotoxicity, PBMC activity, CDX/PDX models, pharmacokinetic analysis, monkey toxicology analysis, etc
4. Have good English reading and writing skills, familiar with the search of various literature.
Have good English reading and writing skills, familiar with searching various types of literature
5. Preferably with CMC or IND experience.
Having CMC and clinical application experience is preferred
6. Good communication skills and execution skills.
Has good communication and execution skills
7. Have good pressure resistance and strong sense of responsibility.
Has good stress resistance and a strong sense of responsibility
8. Have a good sense of teamwork and full of cooperation spirit.
Having a good sense of teamwork and a strong spirit of cooperation
Please send your CV or resume as an attachment to the following email address:
mailto: rbhr@hrcenter.co.uk
With the subject line formatted as: 'Name + Position + Company Name + Location'.