Salary: 23-35k
Experience requirements:Less than 1 year
Educational requirements:PhD
Job Description:
1、 Laboratory Introduction:
Main academic achievements:
Dr. He Jun, doctoral supervisor, selected for the high-level talent project of the Chinese Academy of Sciences, member of the Cryo Electron Microscopy Credit Committee of the Chinese Biophysics Association, and member of the Guangdong Branch of the Chinese Electron Microscopy Society. Mainly studying the high-resolution three-dimensional structural characteristics of biomolecules, utilizing various methods such as cryo electron microscopy reconstruction to investigate the structure and molecular mechanisms of biomolecule machines that play an important role in epigenetic regulation of tumors. The relevant papers have been published in international journals such as Cell Research, Molecular Cell, Nature Microbiology, and Nature Communication
Research field:
The structure and function of eukaryotic chromatin are precisely regulated by numerous epigenetic factors at the temporal and spatial levels, ensuring the orderly progression of life activities. The molecular structure and compositional form of DNA histones and nucleosomes are the basis for the dynamic structural changes of chromatin, and together with other epigenetic factors such as histone variants, histone * *, histone modifying enzymes, and chromatin remodeling complexes, regulate the function of chromatin. The research team is committed to studying the functions and mechanisms of chromatin dynamic regulation, with a focus on important macromolecular machine complexes closely related to tumor development. Through high-resolution structural analysis and functional mechanism research of these complexes at multiple scales, we explore their functions and interaction patterns in the cell fate regulation network, understand their involvement in the pathogenesis of tumor occurrence and development at the molecular level, and based on the obtained key three-dimensional spatial information, discover novel drug target proteins for targeted drug development, including small molecule drugs and monoclonal antibody drugs
2、 Job responsibilities and recruitment requirements:
1. Familiar with histone modification, in vitro assembly of nucleosomes and their variants
2. Familiar with using eukaryotic expression systems for the expression and purification of multi subunit protein complexes
3. Familiar with using cryo electron microscopy technology for protein structure analysis
4. Familiar with small molecule drug screening based on protein structure and molecular and cellular level biochemical experimental verification
5. Those who have obtained or are about to obtain a doctoral degree in the fields of cell biology, materials science, or structural biology within the past two years, and have experience in using transmission electron microscopy for scientific research work, with priority given to those who have experience in tomography or FIB methods
6. Familiar with the Linux operating system, possessing certain programming skills, and mastering at least one language (such as Python, Java, or R/Matlab)
7. Have a strong interest in conducting exploratory work, enjoy delving into problems, possess the ability to think independently and solve problems, have good communication skills and teamwork spirit
3、 Salary and benefits:
1. Provide competitive salary packages, starting from 280000 yuan per year for postdoctoral fellows, to be discussed in person
2. Postdoctoral fellows can determine the direction of their research and re-enter the station; Excellent doctoral and postdoctoral personnel will be included in the management of the Special Research Assistant position at the Chinese Academy of Sciences. Our unit will provide a salary and benefits level equivalent to that of the associate professor position, as well as an international research platform; Excellent candidates can apply for promotion to associate researcher and follow-up researcher, PI, etc., with broad personal development opportunities
3. Establishing good cooperative relationships between laboratories and foreign research institutes or universities is highly encouraged for outstanding postdoctoral students to continue exchanging and collaborating in these laboratories; We will also strongly encourage outstanding postdoctoral graduates to develop on other excellent platforms in the future
4. Encourage the application for national talent projects, Guangzhou Development Zone in Guangdong Province, and other talent projects at all levels to obtain generous talent subsidies and benefits. For example, high-level talents in Guangzhou can receive a talent subsidy of 1-5 million yuan and other generous benefits, which can be combined with their salary
5. High standard payment of five social insurances and one housing fund, comprehensive benefits such as paid annual leave, and assistance in solving children's education, housing and other living problems through multiple channels. Graduates with master's and doctoral degrees can settle in Guangzhou
4、 Job Application Notice:
1. Interested parties are requested to send their personal resume in both Chinese and English, an overview of their past research content and future research interests, and papers published in the past 5 years to the email address: [insert email address]. The email subject should be marked as "He Jun's research group+applied position+name"
2. Our company promises to strictly keep confidential all materials submitted by applicants and conduct preliminary screening and evaluation based on their resume, research achievements, and development potential; After passing the initial review, the specific time, location, and related matters of the interview will be notified via email or phone
3. Applicants who fail the initial review will not be notified separately, and those who do not receive a response within two months will be deemed to have failed the initial review
4. This recruitment information is valid for a long time from the date of publication
Please send your CV or resume as an attachment to the following email address:
mailto: rbhr@hrcenter.co.uk
With the subject line formatted as: 'Name + Position + Company Name + Location'.